March 9, 2013
The Honourable Leona Aglukkaq
Minister of Health, Health Canada
The Right Honourable Stephen Harper
Prime Minister of Canada, email@example.com
David S. Michaud, PhD
Principal Investigator, firstname.lastname@example.org
Dear Minister Aglukkaq,
Re: Health Canada Wind Turbine Noise and Health Study
Attached are several peer reviewed and published references regarding the serious consequences of sleep deprivation.
The purpose of this submission is to inform Health Canada about several references regarding the impact of sleep deprivation which can lead to impairment of health.
Sleep deprivation is a serious issue as evidenced by the attached.
Health Canada is aware there are many reporting sleep deprivation which is correlated with noise including low frequency and infrasound (audible and inaudible) associated with the operations of industrial wind energy facilities.
I have provided a copy of my comments to The Right Honourable Stephen Harper, Prime Minister of Canada and Dr. David Michaud, Principle Investigator, Health Canada.
The contents of this submission should not be used to infer any bias for or against wind energy.
This submission is not to be associated with and/or used to characterize any individual and/or organization.
I have received no financial support for the research, authorship, and/or publication of this submission.
Effects of insufficient sleep on circadian rhythmicity and expression
amplitude of the human blood transcriptome
Carla S. Möller-Levet, Simon N. Archer, Giselda Bucca, Emma E. Laing, Ana Slak, Renata Kabiljo, June C. Y. Lo, Nayantara Santhi, Malcolm von Schantz,
Colin P. Smith, and Derk-Jan Dijk
Published online before print February 25, 2013, doi:10.1073/pnas.1217154110
PNAS (Proceedings of the National Academy of Sciences)
February 25, 2013 201217154http://www.pnas.org/content/early/2013/02/20/1217154110
Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, including obesity, cardiovascular disease, and cognitive impairment, but the mechanisms involved remain largely unexplored. Twenty-six participants were exposed to 1 wk of insufficient sleep (sleep-restriction condition 5.70 h, SEM = 0.03 sleep per 24 h) and 1 wk of sufficient sleep (control condition 8.50 h sleep, SEM = 0.11). Immediately following each condition, 10 whole-blood RNA samples were collected from each participant, while controlling for the effects of light, activity, and food, during a period of total sleep deprivation.
Transcriptome analysis revealed that 711 genes were up- or down-regulated by insufficient sleep. Insufficient sleep also reduced the number of genes with a circadian expression profile from 1,855 to 1,481, reduced the circadian amplitude of these genes, and led to an increase in the number of genes that responded to subsequent total sleep deprivation from 122 to 856. Genes affected by insufficient sleep were associated with circadian rhythms (PER1, PER2, PER3, CRY2, CLOCK, NR1D1, NR1D2, RORA, DEC1, CSNK1E), sleep homeostasis (IL6, STAT3, KCNV2, CAMK2D), oxidative stress (PRDX2, PRDX5), and metabolism (SLC2A3, SLC2A5, GHRL, ABCA1).
Biological processes affected included chromatin modification, gene-expression regulation, macromolecular metabolism, and inflammatory, immune and stress responses. Thus, insufficient sleep affects the human blood transcriptome, disrupts its circadian regulation, and intensifies the effects of acute total sleep deprivation. The identified biological processes may be involved with the negative effects of sleep loss on health, and highlight the interrelatedness of sleep homeostasis, circadian rhythmicity, and metabolism.
Sleep disturbances and suicide risk: A review of the literature
Rebecca A Bernert and Thomas E Joiner
Neuropsychiatr Dis Treat. 2007 December; 3(6): 735–743. PMCID: PMC2656315
A growing body of research indicates that sleep disturbances are associated with suicidal ideation and behaviors. This article (1) provides a critical review of the extant literature on sleep and suicidality and (2) addresses shared underlying neurobiological factors, biological and social zeitgebers, treatment implications, and future directions for research.
Findings indicate that suicidal ideation and behaviors are closely associated with sleep complaints, and in some cases, this association exists above and beyond depression. Several cross-sectional investigations indicate a unique association between nightmares and suicidal ideation, whereas the relationship between insomnia and suicidality requires further study.
Underlying neurobiological factors may, in part, account for the relationship between sleep and suicide. Serotonergic neurotransmission appears to play a critical role in both sleep and suicide. Finally, it remains unclear whether or not sleep-oriented interventions may reduce risk for suicidal behaviors. Unlike other suicide risk factors, sleep complaints may be particularly amenable to treatment. As a warning sign, disturbances in sleep may thus beespecially useful to research and may serve as an important clinical target for future suicide intervention efforts.
Carmen Krogh, BScPharm
Killaloe, ON, K0J 2A0